Publications of PIs and Associates

A01

Heiko Luhmann

Prof. Dr. rer. nat.
Institute of PhysiologyJohannes Gutenberg University Mainz

Halbhuber L, Hirsch C, Luhmann HJ, Sinning A, Kilb W. (2019) Ionic plasticity of the intracellular Cl--concentration can act as coincidence detector for GABAergic and glutamatergic inputs. Front Cell Neurosci 13:497, doi:10.3389/fncel.2019.00497.
Lombardi A, Jedlicka P, Luhmann HJ, Kilb W. (2019) Interactions between Membrane Resistance, GABA-A Receptor Properties, Bicarbonate Dynamics and Cl(-)-Transport Shape Activity-Dependent Changes of Intracellular Cl(-) Concentration. Int J Mol Sci. 20: 1416; doi:10.3390/ijms20061416.
Aparisi Rey A, Karaulanov E, Sharopov S, Arab K, Schäfer A, Gierl M, Guggenhuber S, Brandes C, Pennella L, Gruhn WH, Jelinek R, Maul C, Conrad A, Kilb W, Luhmann HJ, Niehrs C, Lutz B. (2019) Gadd45α modulates aversive learning through post-transcriptional regulation of memory-related mRNAs. EMBO Rep. 20(6); doi: 10.15252/embr.201846022.
Thalman C, Horta G, Qiao L, Endle H, Tegeder I, Cheng H, Laube G, Sigrudsson T, Hauser MJ, Tenzer S, Distler U, Aoki J, Morris AJ, Geisslinger G, Roper J, Kirischuk S, Luhmann HJ, Radyushkin K, Nitsch R, Vogt J. (2018) Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders. Mol Psychiatry 23: 1699-1710.
Luhmann HJ, Khazipov R (2017) Neuronal activity patterns in the developing barrel cortex. Neuroscience 368: 256-267.
Kirischuk S, Sinning A, Blanquie O, Yang JW, Luhmann HJ, Kilb W (2017) Modulation of neocortical development by early neuronal activity: physiology and pathophysiology. Front Cell Neurosci 11: 379; doi: 10.3389/fncel.2017.00379.
Blanquie O, Yang JW, Kilb W, Sharopov S, Sinning A, Luhmann HJ (2017) Electrical activity controls area-specific expression of neuronal apoptosis in the mouse developing cerebral cortex. Elife 6: e27696; doi: 10.7554/eLife.27696.
Blanquie O, Liebmann L, Hübner CA, Luhmann HJ, Sinning A (2017) NKCC1-mediated GABAergic signaling promotes postnatal cell death in neocortical Cajal-Retzius cells. Cereb Cortex 27: 1644-1659.
Blanquie O, Kilb W, Sinning A, Luhmann HJ (2017) Homeostatic interplay between electrical activity and neuronal apoptosis in the developing neocortex. Neuroscience 358: 190-200.
Vogt J, Kirischuk S, Unichenko P, Schluter L, Pelosi A, Endle H, Yang JW, Schmarowski N, Cheng J, Thalman C, Strauss U, Prokudin A, Bharati BS, Aoki J, Chun J, Lutz B, Luhmann HJ, Nitsch R (2017) Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways. Cereb Cortex 27: 131-145.

Anne Sinning

Dr. rer. nat.
Institute of PhysiologyJohannes Gutenberg University Mainz

A05

Benedikt Berninger

Prof. Dr. rer. nat.
Institute for Physiological ChemistryJohannes Gutenberg University Mainz

Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A (2019) Quiescence modulates stem cell maintenance and regenerative capacity in the aging brain. Cell 176: 1407-1419.
Bragado-Alonso S, Reinert JK, Marichal N, Massalini S, Berninger B, Kuner T, Calegari F (2019) An increase in neural stem cells and olfactory bulb adult neurogenesis improves discrimination of highly similar odorants. The EMBO Journal 38 pii: e98791.
Tiwari N, Pataskar A, Péron S, Thakurela S, Sahu SK, Figueres-Oñate M, Marichal N, López-Mascaraque L, Tiwari VK*, Berninger B* (2018) Stage-specific transcription factors drive astrogliogenesis by remodeling gene regulatory landscapes. Cell Stem Cell 23:557-571.
Karow M, Camp JG, Falk S, Gerber T, Pataskar A, Gac-Santel M, Kageyama J, Brazovskaja A, Garding A, Fan W, Riedemann T, Casamassa A, Smiyakin A, Schichor C, Götz M, Tiwari VK, Treutlein B*, Berninger B* (2018) Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program. Nature Neuroscience 21:932-940.
Zhao S, Fan W, Guo X, Xue L, Berninger B, Salierno MJ, Del Campo A (2018) Microenvironments to study migration and somal translocation in cortical neurons. Biomaterials 156: 238-247.
Bicker F, Vasic V, Horta G, Ortega F, Nolte H, Kavyanifar A, Keller S, Stankovic ND, Harter PN, Bendito R, Lutz B, Bäuerle T, Hartwig J, Baumgart J, Krüger M, Radyushkin K, Alberi L, Berninger B, Schmidt MHH (2017) Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nature Communications 8:15922.
Azim K, Angonin D, Marcy G, Pieropan F, Rivera A, Donega V, Cantù C, Williams G, Berninger B, Butt AM, Raineteau O (2017) Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity. PLoS Biology 15(3):e2000698.
Dehorter N, Marichal N, Marín O, Berninger B (2017) Tuning neural circuits by turning the interneuron knob. Current Opinion in Neurobiology 42:144-151.
Other publications:
Herrero-Navarro A, Puche-Aroca L, Moreno-Juan V, Sempere-Ferràndez A, Espinosa A, Susín R, Torres-Masjoan L, Leyva- Díaz E, Karow M, Figueres-Oñate M, López-Mascaraque L, López-Atalaya JP, Berninger B, López-Bendito G. Astrocytes and neurons share brain region-specific transcriptional signatures. bioRxiv 038737; doi: https://doi.org/10.1101/2020.04.21.038737.
Péron S, Miyakoshi LM, Brill MS, Ortega F, Karow M, Gascón S, Berninger B. Programming of neural progenitors of the adult subependymal zone towards a glutamatergic identity by neurogenin2. bioRxiv 171686; doi: https://doi.org/10.1101/171686.

A06

Beat Lutz

Prof. Dr. sc. nat.
Institute for Physiological ChemistryJohannes Gutenberg University Mainz

Aparisi Rey A., Karaulanov E., Sharopov S., Arab K., Schäfer A., Gierl M., Guggenhuber S., Brandes C., Pennella L., Gruhn W.H., Jelinek R., Maul C., Conrad A., Kilb W., Luhmann H.J., Niehrs C.*, Lutz B.* (2019) Gadd45α modulates aversive learning through post-transcriptional regulation of memory-related mRNAs. EMBO Rep. 20(6) *shared senior authors
Schüle K.M., Leichsenring M., Andreani T., Vastolo V., Mallick M., Musheev M.U., Karaulanov E., Niehrs C. (2019). GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cells. Genes Dev. 33, 782-798
Arab K.*, Karaulanov E., Musheev M., Trnka P., Schäfer A., Grummt I.*, and Niehrs C.* (2019). GADD45A binds R-loops and recruits TET1 to CpG island promoters. Nat. Genet. 51, 217-223 *corresponding authors.
Schäfer A., Mekker B., Mallick M., Vastolo V., Karaulanov E., Sebastian D., von der Lippen C., Epe B., Downes D.J., Scholz C., and Niehrs C. (2018). Impaired DNA demethylation of C/EBP sites causes premature aging. Genes Dev. 32, 742-762

Christof Niehrs

Prof. Dr. rer. nat.
Institute for Molecular Biology (IMB)

A11

Jochen Roeper

Prof. Dr. med.
Institute for NeurophysiologyGoethe University Frankfurt

Cooper A, Butto T, Hammer N, Jagannath S, Fend-Guella DL, Akhtar J, Radyushkin K, Lesage F, Winter J, Strand S, Roeper J, Zechner U, Schweiger S (2020) Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome. Nat Commun 11(1):480. doi: 10.1038/s41467-019-13918-4.
Farassat N, Costa KM, Stojanovic S, Albert S, Kovacheva L, Shin J, Egger R, Somayaji M, Duvarci S, Schneider G, Roeper J. (2019) In vivo functional diversity of midbrain dopamine neurons within identified axonal projections eLife Oct 3;8. pii: e48408. doi: 10.7554/eLife.48408
Schwenk J, Boudkkazi S, Kocylowski MK, Brechet A, Zolles G, Bus T, Costa KM, Kollewe A, Jordan J, BankJ, Bildl W, Sprengel R, Kulik A, Roeper J, Schulte U, Fakler B (2019). An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity. Neuron 104(4):680-692
Wagner-Altendorf TA, Fischer B, Roeper J (2019) Axonal projection-specific differences in somatodendritic α2 autoreceptor function in locus coeruleus neurons. Eur J Neurosci 50:3772–3785.
Thakur P, Chiu WH, Roeper J*, Goldberg JA. (2019) α-Synuclein 2.0 - Moving towards Cell Type Specific Pathophysiology. Neuroscience 412:248-256.* corresponding
Duvarci S, Simpson EH, Schneider G, Kandel ER, Roeper J&, Sigurdsson T&. (2018) Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression. Nat Commun. 9(1):2822. &equal contribution
Knowlton C, Kutterer S, Roeper J, Canavier CC. (2018) Calcium dynamics control K-ATP channel-mediated bursting in substantia nigra dopamine neurons: a combined experimental and modeling study. J Neurophysiol. 119(1):84-95
Roeper J. (2018) Closing gaps in brain disease-from overlapping genetic architecture to common motifs of synapse dysfunction. Curr Opin Neurobiol. 48:45-51.
Lasser-Katz, E., Simchovitz, A., Chiu, W.H., Oertel, W.H., Sharon, R., Soreq, H., Roeper, J., and Goldberg, J.A. (2017). Mutant alpha-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease. J Neurosci 37, 47-57.
Other publications
Otomo K, Perkins J, Kulkarni A, Stojanovic S, Roeper J*., and Paladini CA*(2020). Subthreshold repertoire and threshold dynamics of midbrain dopamine neuron firing in vivo. bioRxiv, 2020.2004.2006.028829.

B01

Erin Schuman

Prof. Ph.D.
Max Planck Institute for Brain Research

Alvarez, B, tom Dieck, S., Fusco, C., Perez, J., Donlin-Asp, P., and Schuman, E.M. (2020). The switch-like expression of Heme-regulated kinase 1 mediates neuronal proteastasis following proteasome inhibition. eLife e52714.
Biever, A., Glock, C., Tushev, G., Cirdaeva, E., Langer, J. and Schuman, E.M. (2020). Monosomes actively translate synaptic mRNAs in neuronal processes. Science, 367, 522-524.
Dörrbaum, A.R., Langer, J.D., and Schuman, E.M. (2018). Local and global influences on protein turnover in neurons and glia. eLife, doi: 10.7554/eLife.34202.
Fonkeu, Y*., Kraynyukova, N*., Hafner, AS*., Kochen, L., Sartori, F., Schuman, E.M., Tchumatchenko, T. (2019) How mRNA Localization and Protein Synthesis Sites Influence Dendritic Protein Distribution and Dynamics. Neuron, vol. 103, pp.1109–1122, *equal contribution
Hafner, A.S., Donlin-Asp, P.G., Leitch, B., Herzog, E., and Schuman, E.M. (2019). Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments. Science, 364, (650), doi: 10.1126/science.aau3644.
Heumüller, M., Glock, C., Biever, A., Rangaraju, V. and Schuman, E.M. (2019). A genetically encodable protein synthesis inhibitor. Nature Methods, 16, 699-702.
Rangaraju, V., Lauterbach, M., and Schuman, E.M. (2019). Spatially stable mitochondrial compartments fuel local translation during synaptic plasticity. Cell, 176, 1-12. doi: 10.1016/j.cell.2018.12.013.
Alvarez-Castelao, B., Schanzenbaecher, C.T., Langer, J.D., and Schuman, E.M. (2019). Cell-type-specific metabolic labeling, detection and identification of nascent proteomes in vivo. Nature Protocols, doi: 10.1038/s41596-018-0106-6.
Tushev, G., Glock, C., Heumueller, M., Biever, A., Jovanovic, M., and Schuman, E.M. (2018). Alternative 3’UTRs modify the localization, regulatory potential, stability, and plasticity of mRNAs in neuronal compartments. Neuron, 98, 495-511. doi:10.1016/j.neuron.2018.03.030.
Schanzenbaecher, C.T., Langer, J.D., and Schuman, E.M. (2018). Time- and polarity-dependent proteomic changes associated with homeostatic scaling at central synapses. eLife 2018;7:e33322. doi: https://doi.org/10.7554/eLife.33322
Alvarez-Castelao, B., Schanzenbaecher, C.T., Hanus, C., Glock, C., tom Dieck, S., Dörrbaum, A.R., Bartnik, I., Nassim-Assir, B., Ciirdaeva, E., Mueller, A., Dieterich D.C., Tirrell, D.A., Langer, J.D., Schuman, E.M. (2017). Cell-type-specific metabolic labeling of nascent proteomes in vivo. Nature Biotechnology, 35: 1196-1201. doi:10.1038/nbt.4016

B02

Alexander Gottschalk

Dr. rer. nat., Prof.
Institute for Biochemistry Goethe University Frankfurt

Steuer Costa W, Van der Auwera P, Glock C, Liewald JF, Bach M, Schüler C, Wabnig S, Oranth A, Masurat F, Bringmann H, Schoofs L, Stelzer EHK, Fischer SC, Gottschalk A. (2019) A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics. Nat. Comm. 10: 4095. doi: 10.1038/s41467-019-12098-5.
Azimi Hashemi N, Bergs ACF, Schüler C, Scheiwe AR, Steuer Costa W, Bach M, Liewald JF, Gottschalk A. (2019) Rhodopsinbased voltage imaging tools for use in muscles and neurons of Caenorhabditis elegans. PNAS 116: 17051-60. doi: 10.1073/pnas.1902443116.
Liu Q, Sinnen BL, Boxer EE, Schneider MW, Grybko MJ, Buchta WC, Gibson ES, Wysoczynski CL, Ford CP, Gottschalk A, Aoto J, Tucker CL, Kennedy MJ. (2019) A photoactivatable botulinum toxin for inducible control of neurotransmission. Neuron 101: 863-875. doi: 10.1016/j.neuron.2019.01.002.
Bergs ACF, Schultheis C, Fischer E, Tsunoda SP, Erbguth K, Husson SJ, Govorunova E, Spudich JL, Nagel G, Gottschalk A*, Liewald JF*. (2018) Rhodopsin optogenetic toolbox v2.0 for light-sensitive excitation and inhibition in Caenorhabditis elegans. PLoS ONE 13(2): e0191802. doi: 10.1371/journal.pone.0191802.
Yu S-c*, Jánosi B*, Liewald J, Wabnig S, Gottschalk A. (2018) Endophilin A and B join forces with clathrin to mediate synaptic vesicle recycling in Caenorhabditis elegans. Front. Molec. Neurosci. 11: 196. doi: 10.3389/fnmol.2018.00196.
Tolstenkov O, Van der Auwera P, Steuer Costa W, Bazhanova O, Gemeinhard T, Bergs ACF, Gottschalk A. (2018) Functionally asymmetric motor neurons contribute to coordinating locomotion of Caenorhabditis elegans. eLife 7: e34997. doi: 10.7554/eLife.34997.
Brown J, Behnam R, Coddington L, Tervo DGR, Martin K, Proskurin M, Kuleshova E, Park J, Phillips J, Bergs ACF, Gottschalk A, Dudman JT, Karpova AY. (2018) Expanding the Optogenetics Toolkit by Topological Inversion of Rhodopsins. Cell 175: 1131-1140. doi: 10.1016/j.cell.2018.09.026.
Oranth A*, Schultheis C*, Tolstenkov O, Erbguth K, Nagpal J, Hain D, Brauner M, Wabnig S, Steuer Costa W, McWhirther R, Zels S, Palumbos S, Miller DM III, Beets I, Gottschalk A. (2018) Food sensation modulates locomotion by dopamine and neuropeptide signaling in a distributed neuronal network. Neuron 100: 1414-1428. doi: 10.1016/j.neuron.2018.10.024.
Steuer Costa W, Yu S-c, Liewald JF, Gottschalk A. (2017) Fast cAMP modulation of neurotransmission via neuropeptide signals and vesicle loading. Curr. Biol. 27: 495-507. doi: 10.1016/j.cub.2016.12.055.
Other publications:
Yu S-c*, Steuer Costa W*, Liewald JF*, Shao J, Gottschalk A. (2019) Synapsin is required for dense core vesicle capture and cAMP-dependent neuropeptide release. bioRxiv November 12th. doi: 10.1101/838953.

B03

Thomas Deller

Prof. Dr. med.
Institute for Clinical NeuroanatomyGoethe University Frankfurt

Kur, I.M., Prouvot, P.H., Fu, T., Fan, W. Müller-Braun, F., Das, A., Das, S. Deller, T., Roeper, J., Stroh, A., and Momma, S. (2020) Neuronal activity triggers uptake of hematopoietic extracellular vesicles in vivo. PLoS Biol, 18:e3000643.
Del Turco, D., Paul, M.H., Beeg Moreno, V., Hildebrandt-Einfeldt, L., and Deller, T. (2019) Re-innervation of the denervated dentate gyrus by sprouting associational and commissural mossy cell axons in organotypic tissue cultures of entorhinal cortex and hippocampus. Front Mol Neurosci, 12:270
Lenz, M.*, Galanis, C.*, Kleidonas, D., Fellenz, M., Deller, T., and Vlachos, A. (2019) Denervated mouse dentate granule cells adjust their excitatory but not inhibitory synapses following in vitro entorhinal cortex lesion. Exp Neurol, 312:1-9.
Paul, M., Choi, M., Schlaudraff, J. Deller, T*., and Del Turco, D.* (2019) Granule cell ensembles in mouse dentate gyrus rapidly upregulate the plasticity-related protein Synaptopodin after exploration behavior. Cereb Cortex, 30(4):2185-2198
Strehl, A., Galanis, C., Radic, T., Schwarzacher, S.W.S., Deller, T., and Vlachos, A. (2018) Dopamine modulates homeostatic excitatory synaptic plasticity of immature dentate granule cells in entorhino-hippocampal tissue cultures. Frontiers Mol Neurosci, 11:303.
Jungenitz, T.*, Beining, M.*, Radic, T., Deller, T., Cuntz, H., Jedlicka, P., and Schwarzacher, S.W.S. (2018) Structural homo- and heterosynaptic plasticity in mature and adult newborn rat hippocampal granule cells. Proc Natl Acad Sci USA, 115:E4670-E4679.
Jedlicka, P., and Deller, T. (2017) Understanding the role of synaptopodin and the spine apparatus in Hebbian synaptic plasticity - New perspectives and the need for computational modeling. Neurobiol Learn Mem, 138:21-30.
Schlüter, A., Del Turco. D., Deller, T., Gutzmann, A., Schultz, C., and Engelhardt, M. (2017) Structural Plasticity of Synaptopodin in the Axon Initial Segment during Visual Cortex Development. Cereb Cortex, 27:4662-4675.
Other publications:
Cuntz, H., Bird, A.D., Beining, M., Schneider, M., Mediavilla, L., Hoffmann, F.Z., and Deller, T.*, and Jedlicka, P.* (2019) A general principle of dendritic constancy – a neuron’s size and shape invariant excitability. BioRxiv https://doi.org/10.1101/787911.
Yap, K., Drakew, A., Smilovic, D., Rietsche, M., Del Turco, D., and Deller, T. (2020) The actin-modulating protein Synaptopodin mediates long-term survival of dendritic spines. BioRxiv https://doi.org/10.1101/2020.05.08.080374.

B04

Amparo Acker-Palmer

Prof. PhD.
Institute of Cell Biology and NeuroscienceGoethe University Frankfurt

Segarra M, Aburto MR, Hefendehl J, Acker-Palmer A (2019) Neurovascular Interactions in the Nervous System. Annual Review of Cell and Developmental Biology 35:615-635.
Harde E, Nicholson L, Furones-Cuadrado B, Bissen D, Wigge S, Urban S, Segarra M, Ruiz de Almodovar C, Acker-Palmer A (2019) EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development. eLife; 8. pii: e49819. doi: 10.7554/eLife.49819.
Luck R, Urban S, Karakatsani A, Harde E, Sambandan S, Nicholson L, Haverkamp S, Mann R, Martin-Villalba A, Schuman E, Acker-Palmer A and Ruiz de Almodovar C (2019) VEGF/VEGFR2 signaling regulates hippocampal axon branching during development. eLife; 8. pii: e49818. doi: 10.7554/eLife.49818.
Bissen D, Foss F, Acker-Palmer A (2019) AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking. Cellular and Molecular Life Sciences 76(11):2133-2169.
Haslinger D, Waltes R, Yousaf A, Lindlar S, Schneider I, Lim CK, Tsai MM, Garvalov BK, Acker-Palmer A, Krezdorn N, Rotter B, Acker T, Guillemin GJ, Fulda S, Freitag CM, Chiocchetti AG (2018) Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model. Molecular Autism 9:56.
Segarra M, Aburto MR, Cop F, Llaó-Cid C, Härtl R, Damm M, Bethani I, Parrilla M, Husainie D, Schänzer A, Schlierbach H, Acker T, Mohr L, Torres-Masjoan L, Ritter M, Acker-Palmer A (2018) Endothelial Dab1 signaling orchestrates neuro-gliavessel communication in the central nervous system. Science 2018 361(6404).
Stefani J, Tschesnokowa O, Parrilla M, Robaye B, Boeynaems JM, Acker-Palmer A, Zimmermann H, Gampe K (2018) Disruption of the Microglial ADP Receptor P2Y13 Enhances Adult Hippocampal Neurogenesis. Frontiers in Cellular Neuroscience 12:134.
Beckert B, Acker-Palmer A, Volknandt W (2018) Aβ42 oligomers impair the bioenergetic activity in hippocampal synaptosomes derived from APP-KO mice. Biological Chemistry 399(5):453-465.
Pfennig S, Foss F, Bissen D, Harde E, Treeck JC, Segarra M, Acker-Palmer A (2017) GRIP1 binds to ApoER2 and ephrinB2 to induce activity-dependent AMPA receptor insertion at the synapse. Cell Reports 21:84-96.
Laßek M, Weingarten J, Wegner M, Neupärtl M, Array TN, Harde E, Beckert B, Golghalyani V, Ackermann J, Koch I, Müller UC, Karas M, Acker-Palmer A and Volknandt W (2017) APP Deletion Accounts for Age-Dependent Changes in the Bioenergetic Metabolism and in Hyperphosphorylated CaMKII at Stimulated Hippocampal Presynaptic Active Zones. Frontiers in Synaptic Neuroscience 9:1.

B10

Susann Schweiger

Prof.Dr. med.
Institute for HumangeneticsJohannes Gutenberg University Mainz

Cooper A., Butto T.**, Hammer N.**, Jagannath S., Fend-Guella D.L., Akhtar J., Radyushkin K., Lesage F., Winter J., Strand S., Roeper J.*, Zechner U.*, Schweiger S*. (2020) Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel Intellectual Disability syndrome. Nat Comm 11(1):480.
Distler U**, Schumann S**, Kesseler HG, Pielot R, Smalla KH, Sielaff M, Schmeisser MJ*, Tenzer S* (2020) Proteomic Analysis of Brain Region and Sex-Specific Synaptic Protein Expression in the Adult Mouse Brain. Cells. 9(2).
Kahrizi K, Huber M, Galetzka D, Dewi S, Schröder J, Weis E, Kariminejad A, Fattahi Z, Ropers HH, Schweiger S, Najmabadi H, Winter J (2019) Homozygous variants in the gene SCAPER cause syndromic intellectual disability. Am J Med Genet A. 179(7): 1214-1225.
Modi ME, Brooks JM, Guilmette ER, Beyna M, Graf R, Reim D, Schmeisser MJ, Boeckers TM, O'Donnell P, Buhl DL (2018) Hyperactivity and hypermotivation associated with increased striatal mGluR1 signaling in a Shank2 rat model of autism. Front Mol Neurosci. 11:107.
Arnoux I**, Willam M**, Griesche N, Krummeich J, Watari H, Offermann N, Weber S, Narayan Dey P, Chen C, Monteiro O, Buettner S, Meyer K, Bano D, Radyushkin K, Langston R, Lambert JJ, Wanker E, Methner A, Krauss S*, Schweiger S*, Stroh A* (2018) Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease. Elife. 4;7. pii: e38744.
Schweiger S, Matthes F, Posey K, Kickstein E, Weber S, Hettich MM, Pfurtscheller S, Ehninger D, Schneider R, Krauß S. (2017) Resveratrol induces de-phosphorylation of tau by interfering with the MID1-PP2A complex. Sci Rep. 7(1): 13753.
Reim D**, Distler U**, Halbedl S, Verpelli C, Sala C, Bockmann J, Tenzer S, Boeckers TM*, Schmeisser MJ* (2017) Proteomic Analysis of Post-synaptic Density Fractions from Shank3 Mutant Mice Reveals Brain Region Specific Changes Relevant to Autism Spectrum Disorder. Front Mol Neurosci. 10:26.
Vicidomini C, Ponzoni L, Lim D, Schmeisser MJ, Reim D, Morello N, Orellana D, Tozzi A, Durante V, Scalmani P, Mantegazza M, Genazzani AA, Giustetto M, Sala M, Calabresi P, Boeckers TM, Sala C, Verpelli C (2017) Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice. Mol Psychiatry. 22(5):689–702.

Michael SchmeißerProf. Dr. med. Dr. rer. nat.
Institute for Microscopic Anatomy and NeurobiologyJohannes Gutenberg University Mainz

B11

Jakob von EngelhardProf. Dr. med.
Institute of PathophysiologyJohannes Gutenberg University Mainz

Mehr A, Hick M, Ludewig S, Müller M, Herrmann U, von Engelhardt J, Wolfer DP, Korte M and Müller UC (2020) Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition. Cerebral Cortex. 30(7): 4044–4063
Jacobi E, von Engelhardt J (2020) Modulation of information processing by AMPA receptor auxiliary subunits. J. Physiol. In press
Vasistha NA, Pardo-Navarro M, Gasthaus J, Weijers D, Muller MK, Garcia-Gonzalez D, Malwade S, Korshunova I, Pfisterer U, von Engelhardt J, Hougaard KS, Khodosevich K (2019) Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner. Mol Psychiatry. Oct 8. doi: 10.1038/s41380-019-0539-5
Chen X, Wang D, Kegel M, von Engelhardt J (2019) Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function J. Vis. Exp. 150.
Aslam M, Ullah A, Paramasivam N, Kandasamy N, Naureen S, Badshah M, Khan K, Wajid M, Abbasi R, Eils R, Brockmann MA, Schlesner M, Ahmad N, von Engelhardt J (2019) Segregation and potential functional impact of a rare stop-gain PABPC4L variant in familial atypical Parkinsonism. Sci Rep. 19;9(1)
von Engelhardt J (2019) AMPA receptor auxiliary proteins of the CKAMP family. Intern J Mol Sci 20, 1460; doi:10.3390/ijms20061460.
Müller MK, Jacobi E, Sakimura K, Malinow R, von Engelhardt J (2018) NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Abeta) overexpressing mice. Acta Neuropathol Commun 6:110.
Jacobi E, von Engelhardt J (2018) AMPA receptor complex constituents: Control of receptor assembly, membrane trafficking and subcellular localization. Mol Cell Neurosci 91:67-75.
Chen X, Aslam M, Gollisch T, Allen K, von Engelhardt J (2018) CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus. Nat. Comm. 9: 261.
Jacobi E, von Engelhardt J (2017) Diversity in AMPA receptor complexes in the brain. Curr Opin Neurobiol 45:32-38

B12

Carsten Duch

Prof. Dr.
Institute of DevelopmenalBiology and NeurobiologyJohannes Gutenberg University Mainz

Heine M, Holcman D (2020) Asymmetry Between Pre- and Postsynaptic Transient Nanodomains Shapes Neuronal Communication. Trends Neurosci 43: 182-196.
Schützler N, Girwert C, Hügli I, Mohana G, Roignant JY, Ryglewski S, Duch C (2019) Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust Drosophila locomotion to nutritional state. PNAS 116(9):3805-3810. doi: 10.1073/pnas.1813554116.
Heck J, Parutto P, Ciuraszkiewicz A, Bikbaev A, Freund R, Mitlöhner J, Andres-Alonso M, Fejtova A, Holcman D, Heine M (2019) Transient Confinement of CaV2.1 Ca2+-Channel Splice Variants Shapes Synaptic Short-Term Plasticity. Neuron 103(1):66-79.e12. doi: 10.1016/ j.neuron.2019.04.030.
Brockhaus J, Schreitmüller M, Repetto D, Klatt O, Reissner C, Elmslie K, Heine M, Missler M (2018) α-Neurexins Together with α2δ-1 Auxiliary Subunits Regulate Ca2+ Influx through Cav2.1 Channels. J Neurosci 38(38):8277-8294. doi: 10.1523/JNEUROSCI.0511-18.2018.
Kadas D, Klein A, Krick N, Worrell JW, Ryglewski S, Duch C (2017) Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output during Drosophila Larval Locomotion. J Neurosci 37(45):10971-10982. doi: 10.1523/JNEUROSCI.1064-17.
Ryglewski S, Vonhoff F, Scheckel K, Duch C (2017) Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material. Neuron 8;93(3):632-645.e6. doi: 10.1016/j.neuron.2016.12.043.
Ryglewski S, Kadas D, Hutchinson K, Schuetzler N, Vonhoff F, Duch C (2014) Dendrites are dispensable for basic motoneuron function but essential for fine tuning of behavior. PNAS 111(50):18049-54. doi: 10.1073/pnas.1416247111.
Biermann B, Sokoll S, Klueva J, Missler M, Wiegert JS, Sibarita JB, Heine M (2014) Imaging of molecular surface dynamics in brain slices using single-particle tracking. Nat Commun 5:3024.
Di Biase V, Tuluc P, Campiglio M, Obermair GJ, Heine M, Flucher BE (2011) Surface traffic of dendritic CaV1.2 calcium channels in hippocampal neurons. J Neurosci 31(38):13682-13694.
Ryglewski S, Pflueger HJ, Duch C (2007) Expanding the neuron's calcium signaling repertoire: intracellular calcium release via voltage-induced PLC and IP3R activation. PLoS Biol (4):e66.

Martin Heine

Prof. Dr.
Institute of DevelopmenalBiology and NeurobiologyJohannes Gutenberg University Mainz

C01

Frauke Zipp

Prof. Dr. med.
Clinic for NeurologyJohannes Gutenberg University Mainz

Wasser B, Luchtman D, Löffel J, Robohm K, Birkner K, Stroh A, Vogelaar CF, Zipp F§, Bittner S§ (2020) CNS-localized myeloid cells capture living invading T cells during neuroinflammation. J Exp Med 217: e20190812, doi:10.1084/jem.20190812 §equally contributing and corresponding
Hanuscheck N, Schnatz A, Thalman C, Lerch S, Gärtner Y, Domingues M, Bitar L, Nitsch R, Zipp F, Vogelaar CF (2020) Growth promoting treatment screening for corticospinal neurons in mouse and man. Cell Mol Neurobiol doi: 10.1007/s10571-020-00820-7
Birkner K, Wasser B, Ruck T, Thalman C, Luchtman D, Pape K, Schmaul S, Bitar L, Krämer-Albers EM, Stroh A, Meuth SG, Zipp F§, Bittner S§. (2020) β1-Integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells. J Clin Invest pii: 126381. doi: 10.1172/JCI126381. §equally contributing and corresponding senior authors
Pape K, Tamouza R, Leboyer M, Zipp F (2019) Immunopsychiatry – novel perspectives on brain disorders. Nat Rev Neurol 15:317-328
Vogelaar CF, Mandal S, Lerch S, Birkner K, Birkenstock J, Buhler U, Schnatz A, Raine CS, Bittner S, Vogt J, Kipnis J, Nitsch R, Zipp F. (2018) Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation. Science Translational Medicine. 10: eaao2304
Ellwardt E, Pramanik G, Luchtman D, Novkovic T, Rosales Jubal E, Vogt J, Arnoux I, Vogelaar CF, Mandal S, Schmalz M, Barger Z, Ruiz de Azua I, Kuhlmann T, Lutz B, Mittmann T, Bittner S, Zipp F§, Stroh A§ (2018) Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis. Nat Neurosci 21:1392-1403. §equally contributing and corresponding senior authors
Larochelle C, Uphaus T, Broux B, Gowing E, Paterka M, Michel L, Duvarski Stankovic N, Bicker F, Lemaitre F, Prat A, Schmidt MHH, Zipp F (2018) EGFL7 reduces CNS inflammation in mouse. Nat Commun 9: 8

Christina Vogelaar

Dr. rer. nat.
Clinic for NeurologyJohannes Gutenberg University Mainz

C02

Thomas Mittmann

Prof. Dr. rer. nat.
Institute of PhysiologyJohannes Gutenberg University Mainz

Mohebiany A, Ramphal N, Karram K, Di Liberto G, Novkovic T, Klein M, Marini F, Kreutzfeldt M, Härtner F, Lacher SM, Bopp T, Mittmann T, Merkler D and Waisman A (2020) Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology, Cell Reports, 30:1585-1597.e6. doi: 10.1016/j.celrep.2019.12.097.
Feldmann LK, Le Prieult F, Felzen V, Thal SC, Engelhard K, Behl C, Mittmann T (2019) Proteasome and Autophagy- Mediated Impairment of Late Long-Term Potentiation (l-LTP) after Traumatic Brain Injury in the Somatosensory Cortex of Mice. Int J Mol Sci, 20. doi:10.3390/ijms20123048.
Ellwardt E, Pramanik G, Luchtman D, Novkovic T, Rosales Jubal E, Vogt J, Arnoux I, Vogelaar CF, Mandal, S, Schmalz M, Barger Z, Ruiz de Azua I, Kuhlmann T, Lutz B, Mittmann T, Bittner S, Zipp F & Stroh A (2018) Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis. Nat Neurosci, 21:1392–1403 doi: 10.1038/s41593-018-0274-2.
Sebastiani A, Gölz C, Sebastiani PG, Bobkiewicz W, Behl C, Mittmann T, Thal SC, Engelhard K (2017) Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice. Front Neurosci, 11:678 doi:10.3389/fnins.2017.00678.
Le Prieult F, Thal SC, Engelhard K, Imbrosci B, Mittmann T (2017) Acute Cortical Transhemispheric Diaschisis after Unilateral Traumatic Brain Injury. J Neurotrauma, 34:1097-1110 doi: 10.1089/neu.2016.4575.

Irmgard Tegeder

Prof. Dr. med.
Institute for Clinical PharmacologyGoethe University Frankfurt

C03

Tatjana Tchumatchenko

Dr. rer. nat.
Max Planck Institute for Brain Research

Fonkeu, Y*., Kraynyukova, N*., Hafner, AS*., Kochen, L., Sartori, F., Schuman, E.M., Tchumatchenko, T. (2019) How mRNA Localization and Protein Synthesis Sites Influence Dendritic Protein Distribution and Dynamics. Neuron, vol. 103, pp.1109–1122, *equal contribution
Herfurth, T. and Tchumatchenko, T. (2019) Information transmission of mean and variance coding in integrate-and-fire neurons. Physical Review E, 99, 032420
Herfurth, T. and Tchumatchenko, T. (2019), Quantifying encoding redundancy induced by signal correlations in spike trains of Poisson neurons. Physical Review E 99, 042402
Kraynyukova, N. and Tchumatchenko, T. (2018) Stabilized supralinear network can give rise to bistable, oscillatory and persistent activity. PNAS, 201700080; DOI: 10.1073/pnas.1700080115
Herfurth, T and Tchumatchenko, T. (2017) How linear response shaped models of neural circuits and the quest for alternatives. Current Opinion in Neurobiology, vol.46, p. 234-240.

C04

Gilles Laurent

D.V.M., Ph.D.
Max Planck Institutefor Brain Research

Tosches MA, Yamawaki TM, Naumann RK, Jacobi AA, Tuschev G and Laurent G (2018). Evolution of pallium, hippocampus and cortical cell types revealed by single-cell transcriptomics in reptiles. Science 360 (6391): 881-888.
Tosches MA and Laurent G Evolution of neuronal identity in the cerebral cortex (2019) Curr. Opin. Neurobiol. 56:199-208
Norimoto H, Fenk L, Li H-H, Tosches MA, Gallego-Flores T, Hain D, Reiter S, Kobayashi R, Macias A, Arends A, Klinkmann M, Laurent G (2020). A claustrum in reptiles and its role in slow-wave sleep. Nature 578:413-418.

C05

Yonatan Loewenstein

Prof. Ph.D
Neurobiology and Cognitive Science DeptThe Hebrew University of Jerusalem

Lebovich, L., Darshan, R., Lavi, Y., Hansel, D. and Loewenstein, Y. (2019), Idiosyncratic choice bias in decision tasks naturally emerges from intrinsic stochasticity in neuronal network dynamics, Nat Hum Behav., 3: 1190–1202
Ceballo, S., Bourg, J., Kempf, A., Piwkowska, Z., Daret, A., Deneux, T., Rumpel, S., Bathellier, B. (2019) Cortical Recruitment Determines Learning Dynamics and Strategy. Nat Comm., 10:1479
Mongillo, G., Rumpel, S., Loewenstein, Y. (2018) Inhibitory connectivity defines the realm of excitatory plasticity. Nat Neurosci., 21: 1463–1470
Elber-Dorozko, L. and Loewenstein, Y. (2018) Striatal action-value neurons reconsidered, eLife, 7: e34248.
Aschauer, D., Rumpel, S. (2018) The sensory neocortex and associative memory. Curr Top. Behav. Neurosci. 37:177-211
Chambers, A.R., Rumpel, S. (2017) A stable brain from unstable components: Emerging concepts and implications for neural computation. Neuroscience, 357: 172-184
Mongillo, G., Rumpel, S., Loewenstein, Y. (2017) Intrinsic volatility of synaptic connections — a challenge to the synaptic trace theory of memory. Curr Opin Neurobiol., 46: 7–13
Other:
Aschauer, D.F., Eppler, J.-B., Ewig, L., Chambers, A., Pokorny, C., Kaschube, M., Rumpel, S. (2019) A Basis Set of Elementary Operations Captures Recombination of Neocortical Cell Assemblies During Basal Conditions and Learning. http://dx.doi.org/10.2139/ssrn.3438457 (pre-print)

Simon Rumpel

Prof. Dr. rer. nat.
Institute of PhysiologyJohannes Gutenberg University Mainz

C06

Marion Silies

Prof. Dr.
Institute of DevelopmenalBiology and NeurobiologyJohannes Gutenberg University Mainz

Ketkar MD, Sporar K, Gür B, Ramos-Traslosheros G, Seifert M, Silies M (2020) Luminance Information Is Required for the Accurate Estimation of Contrast in Rapidly Changing Visual Contexts. Current Biology, 30: 657-669
Gür B, Sporar K, Lopez-Behling A, Silies M (2020) Distinct expression of potassium channels regulates visual response properties of lamina neurons in Drosophila melanogaster. J Comp Phys A, 206: 273-287
Molina-Obando S, Vargas-Fique JF, Henning M, Gür B, Schladt TM, Akhtar J, Berger TK, Silies M (2019) ON selectivity in Drosophila vision is a multisynaptic process involving both glutamatergic and GABAergic inhibition. eLife, pii: e49373. doi: 10.7554/eLife.49373
Peng J, Santiago IJ, Ahn C, Gur B, Tsui CK, Su Z, Xu C, Karakhanyan A, Silies M, Pecot MY (2018). Drosophila Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms. eLife 7: e33962. doi:10.7554/eLife.33962
Fisher YE, Leong JCS, Sporar K, Ketkar MD, Gohl DM, Clandinin TR and Silies M (2015) A visual pathway with wide field properties is required for elementary motion detection. Current Biology, 22: 3178 – 3189
Fisher YE*, Silies M* and Clandinin TR (2015) Orientation Selectivity Sharpens Motion Detection in Drosophila. Neuron 88: 390 – 402. *equal contribution
Silies M*, Gohl DM*, Fisher YE, Freifeld L, Clark DA and Clandinin TR (2013) Modular use of peripheral input channels tunes motion-detecting circuitry. Neuron, 79: 111-127 *equal contribution
Silies M, Gohl DM, and Clandinin TR (2014) Motion-Detecting Circuits in Flies: Coming Into View. Annual Review of Neuroscience, 37: 307-327
Burke C, Huetteroth W, Owald D, Perisse E, Krashes M, Das G, Gohl DM, Silies M, Certel S and Waddell S (2012) Layered reward signaling through octopamine and dopamine in Drosophila. Nature, 492: 433-437
Gohl DM, Silies M, Gao XJ, Bhalerao S, Luongo FJ, Lin CC, Potter CJ and Clandinin TR (2011) A genetically convertible enhancer trap for directed combinatorial dissection of gene expression patterns. Nature Methods 8: 231-237

C07

Julijana Gjorgjieva

Prof. Dr.
Max Planck Institute for Brain Research

Montangie, L., Miehl, C. and Gjorgjieva, J. (2020). Autonomous emergence of connectivity assemblies via spike triplet interactions. PLoS Comp Biol 16(5):e1007835. doi.org/10.1371/journal.pcbi.1007835.
Onasch, S. and Gjorgjieva, J. (2020). Circuit stability to perturbations reveals hidden variability in the balance of intrinsic and synaptic conductances. J Neurosci 40 (16) 3186-3202. https://doi.org/10.1523/JNEUROSCI.0985-19.2020.
Field, R.E., D'amour, J.A., Tremblay, R., Miehl, C., Rudy, B., Gjorgjieva, J. and Froemke, R.C. (2020). Heterosynaptic plasticity determines the set-point for cortical excitatory-inhibitory balance. Neuron (online now). https://doi.org/10.1016/j.neuron.2020.03.002 .
Gjorgjieva, J., Meister, M. and Sompolinsky, H. (2019). Functional diversity among sensory neurons from efficient coding principles. PLoS Comp Biol 15(11): e1007476. doi.org/10.1371/journal.pcbi.1007476.
Dalmay, T., Abs, E., Poorthuis, R.B., Onasch, S., Lozano Navarro, Y., Tovote, P., Gjorgjieva, J. and Letzkus, J.J. (2019). A critical role for neocortical processing of threat memory. Neuron 104:1180-1194.e7. doi.org/10.1016/j.neuron.2019.09.025.
Sayin, S., De Backer, J.-F., Siju, K.P., Wosniack, M.E., Lewis, L., Frisch, L.-M., Gansen, B., Schlegel, P., Edmondson-Stait, A., Sharifi, N., Fisher, C.B., Calle-Schuler, S., Lauritzen, S., Bock, D., Costa, M., Jefferis, G.S.X.E., Gjorgjieva, J. and Grunwald Kadow, I.C. (2019). A neural circuit arbitrates between perseverance and reward in hungry Drosophila. Neuron 104:544-558.e6. https://doi.org/10.1016/j.neuron.2019.07.028.
Torrado Pacheco, A., Tilden, E.I., Gruztner, S.M., Lane, B., Wu, Y., Hengen, K.B., Gjorgjieva, J. and Turrigiano, G.G. (2019). Rapid and active stabilization of visual cortical firing rates across light-dark transitions. Proc Natl Acad Sci USA 116:18068-18077.
Miska, N.J., Richter, L.M.A., Cary, B.A., Gjorgjieva, J. and Turrigiano, G.G. (2018). Sensory deprivation inversely regulates feedforward and feedback excitation-inhibition ratio in rodent visual cortex. eLife 7:e38846 doi: 10.7554/eLife.38846.
Richter, L.M.A. and Gjorgjieva, J. (2017). Understanding neural circuit development through theory and models. Curr Opin Neurobiol 46:39-47.
Gjorgjieva, J., Evers, J.F. and Eglen, S.J. (2016). Homeostatic activity-dependent tuning of recurrent networks for robust propagation of activity. J Neurosci 36:3722–3734.

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