Publications

Information as at October 2018.

A01 Luhmann / Sinning

Blanquie O, Kilb W, Sinning A, Luhmann HJ (2017a) Homeostatic interplay between electrical activity and neuronal apoptosis in the developing neocortex. Neuroscience 358: 190-200.

Blanquie O, Liebmann L, Hübner CA, Luhmann HJ, Sinning A (2017b) NKCC1-mediated GABAergic signaling promotes postnatal cell death in neocortical Cajal-Retzius cells. Cereb Cortex 27: 1644-1659.

Blanquie O, Yang JW, Kilb W, Sharopov S, Sinning A, Luhmann HJ (2017c) Electrical activity controls area-specific expression of neuronal apoptosis in the mouse developing cerebral cortex. Elife 6: e27696.

Kirischuk S, Sinning A, Blanquie O, Yang JW, Luhmann HJ, Kilb W (2017) Modulation of Neocortical Development by Early Neuronal Activity: Physiology and Pathophysiology. Front Cell Neurosci 11: 379.

Luhmann HJ (2017) Review of imaging network activities in developing rodent cerebral cortex in vivo. Neurophotonics 4: 031202.

Luhmann HJ, Khazipov R (2017) Neuronal activity patterns in the developing barrel cortex. Neuroscience 368: 256-267.

Thalman C, Horta G, Qiao L, Endle H, Tegeder I, Cheng H, Laube G, Sigrudsson T, Hauser MJ, Tenzer S, Distler U, Aoki J, Morris AJ, Geisslinger G, Roper J, Kirischuk S, Luhmann HJ, Radyushkin K, Nitsch R, Vogt J (2018) Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders. Mol Psychiatry 23: 1699-1710.

Unichenko P, Yang JW, Kirischuk S, Kolbaev S, Kilb W, Hammer M, Krueger-Burg D, Brose N, Luhmann HJ (2018) Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex. Cereb Cortex 28: 2873-2886.

Vogt J, Kirischuk S, Unichenko P, Schluter L, Pelosi A, Endle H, Yang JW, Schmarowski N, Cheng J, Thalman C, Strauss U, Prokudin A, Bharati BS, Aoki J, Chun J, Lutz B, Luhmann HJ, Nitsch R (2017) Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways. Cereb Cortex 27: 131-145.

A03 Schmidt

Peer-reviewed original articles

Nevenka Dudvarski Stanković, Frank Bicker, Stefanie Keller, David T. W. Jones, Patrick N. Harter, Arne Kienzle, Clarissa Gillmann, Philipp Arnold, Anna Golebiewska, Olivier Keunen, Alf Giese, Andreas von Deimling, Tobias Bäuerle, Simone P. Niclou, Michel Mittelbronn, Weilan Ye, Stefan Pfister & Mirko H.H. Schmidt (2018) EGFL7 enhances surface expression of integrin alpha5beta1 to promote angiogenesis in malignant brain tumors. EMBO Molecular Medicine pii: e8420

Catherine Larochelle, Timo Uphaus, Bieke Broux, Elizabeth Gowing, Magdalena Paterka, Laure Michel, Nevenka Dudvarski Stankovic, Frank Bicker, Alexandre Prat*, Mirko HH Schmidt* & Frauke Zipp* (2018) EGFL7 reduces CNS inflammation in mouse. Nature Communications 9(1):819. *Equal contribution

Frank Bicker, Verica Vasic, Guilherme Horta, Felipe Ortega, Hendrik Nolte, Atria Kavyanifar, Stefanie Keller, Nevenka Dudvarski Stankovic, Patrick N. Harter, Rui Benedito, Beat Lutz, Tobias Bäuerle, Jens Hartwig, Jan Baumgart, Marcus Krüger, Konstantin Radyushkin, Lavinia Alberi, Benedikt Berninger & Mirko HH Schmidt (2017) Neurovascular EGFL7 regulates subventricular neural stem cells, neurogenesis and olfactory perception. Nature Communications 28(8):15922

Peer-reviewed reviews

Christina Altmann & Mirko HH Schmidt (2018) The Role of Microglia in Diabetic Retinopathy: Inflammation, Microvasculature Defects and Neurodegeneration. International Journal of Molecular Sciences 19 (1), pii: E110

Stefanie Keller & Mirko HH Schmidt (2017) The contribution of epidermal growth factor receptor EGFR and its mutant EGFRvIII to glioma cell invasion. International Journal of Molecular Sciences 18 (6), pii: E1295

Verica Vasić & Mirko HH Schmidt (2017) Resilience and vulnerability to pain and inflammation in the hippocampus. International Journal of Molecular Sciences 18 (4), pii: E739

A03 Tegeder

Valek L; Heidler J; Scheving R; Wittig I; Tegder I, Nitric oxide contributes to protein homeostasis by S-nitrosylations of the chaperone HSPA8 and the ubiquitin ligase UBE2D. Redox Biol (2018) DOI: 10.1016/j.redox.2018.10.002. doi: 10.1016/j.redox.2018.10.002


Thalman C; Horta G; Qiao L; Endle H; Tegeder I; Cheng H; Laube G; Sigrudsson T; Hauser MJ; Tenzer S; Distler U; Aoki J; Morris AJ; Geisslinger G; Roper J; Kirischuk S; Luhmann HJ; Radyushkin K; Nitsch R; Vogt J, Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders. Mol. Psychiatry (2018) 10.1038/s41380-018-0053-1. doi: 10.1038/s41380-018-0053-1


Tegeder I, Nitric oxide mediated redox regulation of protein homeostasis submitted (2018). doi:


Schmitz K; Wilken-Schmitz A; Vasic V; Schmidt MHH; Tegeder I, Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice. submitted (2018).


Schafer MKE; Tegeder I, NG2/CSPG4 and progranulin in the posttraumatic glial scar. Matrix Biol. (2018) 68-69, 571-588. doi: 10.1016/j.matbio.2017.10.002


Hardt S; Valek L; Zeng-Brouwers J; Wilken-Schmitz A; Schaefer L; Tegeder I, Progranulin Deficient Mice Develop Nephrogenic Diabetes Insipidus. Aging Dis. (2018) 9, (5), 817-830. doi: 10.14336/ad.2017.1127


Hardt S; Fischer C; Wilken-Schmitz A; Tegeder I, Distal infraorbital nerve injury, DIONI: a model for persistent facial pain in mice. submitted (2018).


Valek L; Haussler A; Drose S; Eaton P; Schroder K; Tegeder I, Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain. Redox Biol (2017) 11, 176-191. doi: 10.1016/j.redox.2016.12.004


Torres-Odio S; Key J; Hoepken HH; Canet-Pons J; Valek L; Roller B; Walter M; Morales-Gordo B; Meierhofer D; Harter PN; Mittelbronn M; Tegeder I; Gispert S; Auburger G, Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation. J. Neuroinflammation (2017) 14, (1), 154. doi: 10.1186/s12974-017-0928-0


Schmitz K; Brunkhorst R; de Bruin N; Mayer CA; Haussler A; Ferreiros N; Schiffmann S; Parnham MJ; Tunaru S; Chun J; Offermanns S; Foerch C; Scholich K; Vogt J; Wicker S; Lotsch J; Geisslinger G; Tegeder I, Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis. Acta Neuropathol Commun (2017) 5, (1), 42. doi: 10.1186/s40478-017-0446-4


Menzel L; Kleber L; Friedrich C; Hummel R; Dangel L; Winter J; Schmitz K; Tegeder I; Schafer MK, Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury. Glia (2017) 65, (2), 278-292. doi: 10.1002/glia.23091


Lotsch J; Weyer-Menkhoff I; Tegeder I, Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings. Eur. J. Pain (2017) 21, (10). doi:


Kallenborn-Gerhardt W; Moser CV; Lorenz JE; Steger M; Heidler J; Scheving R; Petersen J; Kennel L; Flauaus C; Lu R; Edinger AL; Tegeder I; Geisslinger G; Heide H; Wittig I; Schmidtko A, Rab7-a novel redox target that modulates inflammatory pain processing. Pain (2017) 158, (7), 1354-1365. doi: 10.1097/j.pain.0000000000000920


Hardt S; Heidler J; Albuquerque B; Valek L; Altmann C; Wilken-Schmitz A; Schafer MKE; Wittig I; Tegeder I, Loss of synaptic zinc transport in progranulin deficient mice may contribute to progranulin-associated psychopathology and chronic pain. Biochim. Biophys. Acta (2017) 1863, (11), 2727-2745. doi: 10.1016/j.bbadis.2017.07.014

A05 Berninger

Tiwari N, Pataskar A, Péron S, Thakurela S, Sahu SK, Figueres-Oñate M, Marichal N, López-Mascaraque L, Tiwari VK, Berninger B. Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes. Cell Stem Cell. 2018 Oct 4;23(4):557-571.e8. doi: 10.1016/j.stem.2018.09.008.

Karow M, Camp JG, Falk S, Gerber T, Pataskar A, Gac-Santel M, Kageyama J, Brazovskaja A, Garding A, Fan W, Riedemann T, Casamassa A, Smiyakin A, Schichor C, Götz M, Tiwari VK, Treutlein B, Berninger B. Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program. Nat Neurosci. 2018 Jul;21(7):932-940. doi: 10.1038/s41593-018-0168-3. Epub 2018 Jun 18.

Karakatsani A, Marichal N, Urban S, Kalamakis G, Ghanem A, Schick A, Zhang Y, Conzelmann KK, Rüegg MA, Berninger B, Ruiz de Almodovar C, Gascón S, Kröger S. Neuronal LRP4 regulates synapse formation in the developing CNS. Development. 2017 Dec 15;144(24):4604-4615. doi: 10.1242/dev.150110. Epub 2017 Oct 23.

Bicker F, Vasic V, Horta G, Ortega F, Nolte H, Kavyanifar A, Keller S, Stankovic ND, Harter PN, Benedito R, Lutz B, Bäuerle T, Hartwig J, Baumgart J, Krüger M, Radyushkin K, Alberi L, Berninger B, Schmidt MHH. Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nat Commun. 2017 Jun 28;8:15922. doi: 10.1038/ncomms15922.

Dehorter N, Marichal N, Marín O, Berninger B. Tuning neural circuits by turning the interneuron knob. Curr Opin Neurobiol. 2017 Feb;42:144-151. doi: 10.1016/j.conb.2016.12.009. Epub 2017 Jan 11. Review.

A06 Lutz

None as at October 2018.

A06 Niehrs

Schäfer A, Mekker B, Mallick M, Vastolo V, Karaulanov E, Sebastian D, von der Lippen C, Epe B, Downes DJ, Scholz C and Niehrs C. (2018). Impaired DNA demethylation of C/EBP sites causes premature aging. Genes Dev, 32: 742–762.

Knuckles P, Carl SH, Musheev M, Niehrs C, Wenger A and Bühler M. (2017). RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding. Nat Struct Mol Biol, 24: 561–569.

Schomacher L, Han D, Musheev MU, Arab K, Kienhofer S, von Seggern A and Niehrs C. (2016). Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation. Nat Struct Mol Biol, 23: 116–124.

A11 Roeper

Duvarci S, Simpson EH, Schneider G, Kandel ER, Roeper J*, Sigurdsson T* (shared senior author). Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression.

Nat Commun. 2018 Jul 19;9(1):2822. doi: 10.1038/s41467-018-05214-4.

Roeper J. Closing gaps in brain disease-from overlapping genetic architecture to common motifs of synapse dysfunction.

Curr Opin Neurobiol. 2018 Feb;48:45-51. doi: 10.1016/j.conb.2017.09.007. Epub 2017 Sep 29. Review.

Hauser MJ, Isbrandt D, Roeper J. Disturbances of novel object exploration and recognition in a chronic ketamine mouse model of schizophrenia. Behav Brain Res. 2017 Aug 14;332:316-326. doi: 10.1016/j.bbr.2017.06.013. Epub 2017 Jun 17.

Gärtner M, Duvarci S, Roeper J, Schneider G. Detecting joint pausiness in parallel spike trains.

J Neurosci Methods. 2017 Jun 15;285:69-81. doi: 10.1016/j.jneumeth.2017.05.008. Epub 2017 May 8.

Lasser-Katz E, Simchovitz A, Chiu WH, Oertel WH, Sharon R, Soreq H, Roeper J, Goldberg JA. Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease.

J Neurosci. 2017 Jan 4;37(1):47-57. doi: 10.1523/JNEUROSCI.1079-16.2016.

Messer M, Costa KM, Roeper J, Schneider G. Multi-scale detection of rate changes in spike trains with weak dependencies. J Comput Neurosci. 2017 Apr;42(2):187-201. doi: 10.1007/s10827-016-0635-3. Epub 2016 Dec 26.

Kaue Machado Costa Thesis:

Kaue Machado Costa, Jochen Roeper. Deletion of the alternative splice variant KChIP4a in midbrain dopamine neurons selectively enhances extinction learning. bioRxiv 344499; doi: https://doi.org/10.1101/344499

B01 Schuman

Elamri, I., Heumüller, M. Herzig, L.-M., Stirnal, E., Wachtveitl, J., Schuman, E.M., and Schwalbe, H. (2018). A new photocaged puromycin for an efficient labeling of newly translated proteins in living neurons. ChemBioChem, in press.

Dörrbaum, A.R., Kochen, L., Langer, J.D., and Schuman, E.M. (2018). Local and global influences on protein turnover in neurons and glia. eLife 2018,

doi: 10.7554/eLife.34202.

Tushev, G., Glock, C., Heumueller, M., Biever, A., Jovanovic, M., and Schuman, E.M. (2018). Alternative 3’UTRs modify the localization, regulatory potential, stability, and plasticity of mRNAs in neuronal compartments. Neuron, 98, 495-511. doi:10.1016/j.neuron.2018.03.030.

Schanzenbaecher, C.T., Langer, J.D., and Schuman, E.M. (2018). Time- and polarity-dependent proteomic changes associated with homeostatic scaling at central synapses. eLife 2018;7:e33322. doi: https://doi.org/10.7554/eLife.33322

Alvarez-Castelao, B., Schanzenbaecher, C.T., Hanus, C., Glock, C., tom Dieck, S., Dörrbaum, A.R., Bartnik, I., Nassim-Assir, B., Ciirdaeva, E., Mueller, A., Dieterich D.C., Tirrell, D.A., Langer, J.D., Schuman, E.M. (2017). Cell-type-specific metabolic labeling of nascent proteomes in vivo. Nature Biotechnology, 35: 1196-1201. doi:10.1038/nbt.4016

Glock, C., Heumüller, M., and Schuman, E.M. (2017). mRNA transport & local translation in neurons. Current Opinion in Neurobiology, 45: 169-177. doi: 10.1016/j.conb.2017.05.005

Rangaraju, V., tom Dieck, S., and Schuman, E.M. (2017). Local translation in neuronal compartments: how local is local? EMBO Reports, 18(5): 693-711.

doi: 10.15252/embr.201744045

Sambandan, S., Akbalik, G., Kochen, L., Rinne, J., Kahlstatt, J., Glock, C., Tushev, G., Alvarez-Castelao, B., Heckel, A., and Schuman, E.M. (2017). Activity-dependent spatially localized miRNA maturation in neuronal dendrites. Science, 355 (6325), 634-637.

Akbalik, G., Langebeck-Jensen, K., Tushev, G., Sambandan, S., Rinne, J., Epstein, I., Cajigas, I.J., Vlatkovic, I., and Schuman, E.M. (2017). Visualization of newly synthesized neuronal RNA in vitro and in vivo using click-chemistry. RNA Biology, 14(1):20-28. doi: 10.1080/15476286.2016.1251541. Epub 2016

B02 Gottschalk

Steuer Costa, W., Yu, S.C., Liewald, J.F., and Gottschalk, A. (2017). Fast cAMP Modulation of Neurotransmission via Neuropeptide Signals and Vesicle Loading. Curr Biol 27, 495-507.

Fischer, E., Gottschalk, A., and Schuler, C. (2017). An optogenetic arrhythmia model to study catecholaminergic polymorphic ventricular tachycardia mutations. Scientific reports 7, 17514.

Bergs, A., Schultheis, C., Fischer, E., Tsunoda, S.P., Erbguth, K., Husson, S.J., Govorunova, E., Spudich, J.L., Nagel, G., Gottschalk, A., and Liewald, J.F. (2018). Rhodopsin optogenetic toolbox v2.0 for light-sensitive excitation and inhibition in Caenorhabditis elegans. PLoS One 13, e0191802.

Yu, S.C., Jánosi, B., Liewald, J.F., Wabnig, S., and Gottschalk, A. (2018). Endophilin A and B join forces with clathrin to mediate synaptic vesicle recycling in Caenorhabditis elegans. Front Molec Neurosci 11, 196.

Tolstenkov, O., Van der Auwera, P., Steuer Costa, W., Bazhanova, O., Gemeinhardt, T.M., Bergs, A.C., and Gottschalk, A. (2018). Functionally asymmetric motor neurons contribute to coordinating locomotion of Caenorhabditis elegans. eLife 7.

Brown, J., Behnam, R., Coddington, L., Tervo, D.G.R., Martin, K., Proskurin, M., Kuleshova, E., Park, J., Phillips, J., Bergs, A.C.F., et al. (2018). Expanding the Optogenetics Toolkit by Topological Inversion of Rhodopsins. Cell. Online October 18th.

Oranth, A., Schultheis, C., Tolstenkov, O., Erbguth, K., Nagpal, J., Hain, D., Brauner, M., Wabnig, S., Steuer Costa, W., McWhirter, R.D., et al. Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network. Neuron. Online November 1st.

B03 Deller

Cooperations (Dec. 2016):


Altmann C, Hardt S, Fischer C, Heidler J, Lim HY, Häussler A, Albuquerque B, Zimmer B, Möser C, Behrends C, Koentgen F, Wittig I, Schmidt MH, Clement AM, Deller T, Tegeder I (2016) Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy.

Neurobiol Dis 96:294-311.


Original publications (2017):


Lenz M, Ben Shimon M, Deller T, Vlachos A, Maggio N. (2017) Pilocarpine-Induced Status Epilepticus Is Associated with Changes in the Actin-Modulating Protein Synaptopodin and Alterations in Long-Term Potentiation in the Mouse Hippocampus. Neural Plast 2017:2652560.

Radic T, Jungenitz T, Singer M, Beining M, Cuntz H, Vlachos A, Deller T, Schwarzacher SW (2017) Time-lapse imaging reveals highly dynamic structural maturation of postnatally born dentate granule cells in organotypic entorhino-hippocampal slice cultures. Sci Rep 7:43724.

Schlüter A, Del Turco D, Deller T, Gutzmann A, Schultz C, Engelhardt M (2017) Structural Plasticity of Synaptopodin in the Axon Initial Segment during Visual Cortex Development. Cereb Cortex 27:4662-4675.

Review (2017):


Jedlicka P, Deller T (2017) Understanding the role of synaptopodin and the spine apparatus in Hebbian synaptic plasticity - New perspectives and the need for computational modeling. Neurobiol Learn Mem 138:21-30.

Book Chapter (2017):


Platschek S, Cuntz H, Deller T, Jedlicka P (2017) Lesion-induced dendritic remodeling as a new mechanism of homeostatic structural plasticity in the adult brain. In: van Ooyen A, Butz-Ostendorf M, eds., The Rewiring Brain: A Computational Approach to Structural Plasticity in the Adult Brain. San Diego: Academic Press, 2017: pp. 204-221.

Publications 2018

Jungenitz T*, Beining M*, Radic T, Deller T, Cuntz H, Jedlicka P, Schwarzacher SWS (2018) Structural homo- and heterosynaptic plasticity in mature and adult newborn rat hippocampal granule cells. Proc Natl Acad Sci USA 115:E4670-E4679.

Radic T, Frieß L, Vijikumar A, Jungenitz T, Deller T, Schwarzacher SW (2018) Differential Postnatal Expression of Neuronal Maturation Markers in the Dentate Gyrus of Mice and Rats Front Neuroanat 11:104.

Strehl A, Galanis C, Radic T, Schwarzacher SWS, Deller T, Vlachos A (2018) Dopamine modulates homeostatic excitatory synaptic plasticity of immature dentate granule cells in entorhino-hippocampal tissue cultures Frontiers Mol Neurosci 11:303.

B04 Acker-Palmer

Segarra M, Aburto MR, Cop F, Llaó-Cid C, Haertl R, Damm M, Bethani I, Parrilla M, Husainie D, Schänzer A Schlierbach H, Acker T, Mohr L, Torres-Masjoan L, Ritter M, Acker-Palmer A. Endothelial Dab1 Signaling Orchestrates Neuro-glia-vessel Communication in the CNS. Science, in press (2018).

Dopeso H, Jiao HK, Cuesta AM, Henze AT, Jurida L, Kracht M, Acker-Palmer A, Garvalov BK, Acker T. PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα. Cancer Res. 2018 Apr 1;78(7):1805-1819.

Stefani J, Tschesnokowa O, Parrilla M, Robaye B, Boeynaems JM, Acker-Palmer A, Zimmermann H, Gampe K. Disruption of the Microglial ADP Receptor P2Y13 Enhances Adult Hippocampal Neurogenesis.Front Cell Neurosci. 2018 May 17;12:134.

Pfennig S, Foss F, Bissen D, Harde E, Treeck JC, Segarra M, Acker-Palmer A. GRIP1 Binds to ApoER2 and EphrinB2 to Induce Activity-Dependent AMPA Receptor Insertion at the Synapse. Cell Rep. Oct 3;21(1):84-96 (2017).

B05 Vogt

Thalman C, Horta G, Qiao L, Endle H, Tegeder I, Cheng H, Laube G, Sigrudsson T, Hauser MJ, Tenzer S, Distler U, Aoki J, Morris AJ, Geisslinger G, Röper J, Kirischuk S, Luhmann HJ, Radyushkin K, Nitsch R, Vogt J (2018a) Astrocytic ATX fuels synaptic phospholipid signaling involved in psychiatric disorders. Molecular psychiatry 23:1685-1686.

Thalman C, Horta G, Qiao L, Endle H, Tegeder I, Cheng H, Laube G, Sigrudsson T, Hauser MJ, Tenzer S… Vogt J. (2018) Synaptic phospholipids as a new target for cortical hyperexcitability and E/I-balance in psychiatric disorders. Molecular Psychiatry 23:1699-1710

Schneider P, Petzold S, Sommer A, Nitsch R, Schwegler H, Vogt J*, Roskoden T*. (2018) Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders. A “Forrest Gump” mouse? Behav Brain Res 336:1-7 (*equal contributing last authors)

Vogt J, Kirischuk S, Unichenko P, Schlüter L, Pelosi A, Cheng J, Yang JW, Strauss U, Prokudin A, Bharati Bs et al. (2017) Synaptic phospholipid signaling modulates synchronized cortical activity during brain development altering adult connectivity and memory. Cerebral Cortex 27(1):131-145


Related to CRC 1080:

Gonzales-Escamilla G, Muthuraman M, Chirumamilla VC, Vogt J, Groppa S. (2018) Brain networks reorganization during maturation and healthy aging - emphases for resilience. Frontiers in Psychiatry in press

Gonzales-Escamilla G, Chirumamilla VC, Meyer B, Bonertz T, von Grotthus S, Vogt J, Stroh A, Horstmann JO, Tüscher O, Kalisch R, Muthuraman M, Groppa S. (2018) Excitability regulation in the dorsomedial prefrontal crotex during sustained instructed fear responses: a TMS-EEG study. Science Reports in press

Vogelaar CF, Mandal S, Lerch S, Birkner K, Birkenstock J, Bühler U, Schnatz A, Raine CS, Bittner S, Vogt J, Kipnis J, Nitsch R, Zipp F (2018) Fast direct signaling via the IL-4 receptor as therapeutic target in neuroinflammation Science Translational Medicine 10(430)

Ellwardt E, Pramanik G, Luchtmann D, Novkovic T, Jubal ER, Vogt J, Arnoux I, Vogelaar CF, Mandal S, Schmalz M, BArger Z, de Azua IR, Kuhlmann T, Lutz B, Mittmann T, Bittner S, Zipp F, Stroh A (2018) "Maladaptive cortical hyperactivity follows inflammatory attack on the brain." Nature Neuroscience 21(10):1392-1403

Schmitz K, Brunkhorst R, de Bruin N, Mayer C, Ferreiros N, Häussler A, Schiffmann S, Parnham M, Tunaru S, Chun J, Offermanns S, Förch C, Scholich K, Vogt J, Wicker S, Lötsch J, Geisslinger G, Tegeder I. (2017) Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis. Acta Neuropathologica Communications 5:42

B09 Behl/Clement

Feldmann A, Bekbulat F, Huesmann H, Ulbrich S, Tatzelt J, Behl C, Kern A. The RAB GTPase RAB18 modulates macroautophagy and proteostasis. Biochem Biophys Res Commun. 2017 May 6;486(3):738-743.

Anna S Besemer1, Joanna Maus1, Mirjam D Ax1, Anna Stein1, Christian Freese1, Karsten Nalbach1, Christian von Hilchen1, Ingrid Koziollek-Drechsler1, Heike Huesmann1, Fatima Boukhallouk2, Luise Florin2, Andreas Kern1, Christian Behl1,#, Albrecht M Clement1,#; Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a new component of the proteostasis network and modulates autophagy. (Submitted)

B10 Schweiger

Arnoux I1#, Willam M2#, Griesche N3#, Krummeich J4, Watari H1, Offermann N3, Weber S3, Narayan Dey P5, Chen C6, Monteiro O6, Buettner S3, Meyer K3, Bano D3, Radyushkin K7, Langston R6, Lambert JJ6, Wanker E8, Methner A9, Krauss S3*, Schweiger S4*, Stroh A1*. (2018) Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease. Elife. 2018 Sep 4;7. pii: e38744. doi: 10.7554/eLife.38744. [Epub ahead of print]

Monteiro O, Chen C, Bingham R, Argyrou A, Buxton R, Pancevac Jönsson C, Jones E, Bridges A, Gatfield K, Krauß S, Lambert J, Langston R, Schweiger S, Uings I. (2018) Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures. Neurosci Lett. Feb 27;673:44-50. doi: 10.1016/j.neulet.2018.02.061. [Epub ahead of print]

Schweiger S1, Matthes F2, Posey K3, Kickstein E4, Weber S2, Hettich MM2, Pfurtscheller S5, Ehninger D2, Schneider R5, Krauß S6. (2017) Resveratrol induces de-phosphorylation of tau by interfering with the MID1-PP2A complex. Sci. Rep. Oct. 23;7(1): 13753

B11 von Engelhardt

Müller MK, Jacobi E, Sakimura K, Malinow R, von Engelhardt J (2018) NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Abeta) overexpressing mice. Acta Neuropathol Commun 6:110.

Jacobi E, von Engelhardt J (2018) AMPA receptor complex constituents: Control of receptor assembly, membrane trafficking and subcellular localization. Mol Cell Neurosci 91:67-75.

Chen X, Aslam M, Gollisch T, Allen K, von Engelhardt J (2018) CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus. Nat. Comm. 9: 261.

Jacobi E, von Engelhardt J (2017) Diversity in AMPA receptor complexes in the brain. Curr Opin Neurobiol 45:32-38.

C01 Zipp

Published:

Ellwardt E*, Pramanik G*, Luchtman D, Novkovic T, Rosales Jubal E, Vogt J, Arnoux I, Vogelaar CF, Mandal S, Schmalz M, Barger Z, Ruiz de Azua I, Kuhlmann T, Lutz B, Mittmann T, Bittner S, Zipp F§, Stroh A§ (2018) Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis. Nat Neurosci 21(10):1392-1403. *equally contributing, §equally contributing and corresponding

Vogelaar CF*, Mandal S*, Lerch S*, Birkner K, Birkenstock J, Bühler U, Schnatz A, Raine CS, Bittner S, Vogt J, Kipnis J, Nitsch R, Zipp F (2018) Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation. Sci Transl Med 10:eaao2304. *equally contributing

Larochelle C*, Uphaus T*, Broux B, Gowing E, Paterka M, Michel L, Dudvarski Stankovic N, Bicker F, Lemaître F, Prat A§, Schmidt MHH§, Zipp F§ (2018) EGFL7 reduces CNS inflammation in mouse. Nat Commun 9:819. *,§equally contributing

In Revision:

Pape K, Tamouza R, Leboyer M§, Zipp F§ (2018) Immunoneuropsychiatry - novel perspectives on brain disorders. Nat Rev Neurol. In Revision. §equally contributing

C01 Kipnis

Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease.

Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S, Farber E, Raper D, Viar KE, Powell RD, Baker W, Dabhi N, Bai R, Cao R, Hu S, Rich SS, Munson JM, Lopes MB, Overall CC, Acton ST, Kipnis J.

Nature. 2018 Aug;560(7717):185-191. doi: 10.1038/s41586-018-0368-8. Epub 2018 Jul 25.

C02 Mittmann

Abidin İ, Aydin-Abidin S, Mittmann T. (2018)

Neuronal excitability and spontaneous synaptic transmission in the entorhinal cortex of BDNF heterozygous mice.

Neurosci Lett. 2018 Oct 11;690:69-75. doi: 10.1016/j.neulet.2018.10.019

Ellwardt E, Pramanik G, Luchtman D, Novkovic T, Rosales Jubal E, Vogt J, Arnoux I, Vogelaar CF, Mandal S, Schmalz M, Barger Z, Ruiz de Azua I, Kuhlmann T, Lutz B, Mittmann T, Bittner S, Zipp F & Stroh A (2018)

Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis

Nature Neuroscience 21:1392–1403

Sebastiani A, Gölz C, Sebastiani PG, Bobkiewicz W, Behl C, Mittmann T, Thal SC, Engelhard K. (2017)

Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice. Front Neurosci. 2017 Dec 19;11:678

Wang Q, Mergia E, Koesling D, Mittmann T. (2017)

Nitric oxide/cGMP signaling via guanylyl cyclase isoform 1 modulates glutamate and GABA release in somatosensory cortex of mice. Neuroscience. 360:180-189.

Le Prieult F, Thal SC, Engelhard K, Imbrosci B, Mittmann T. (2017)

Acute Cortical Transhemispheric Diaschisis after Unilateral Traumatic Brain Injury.

J. Neurotrauma. 34(5):1097-1110

C03 Tchumatchenko

Nataliya Kraynyukova and Tatjana Tchumatchenko,

Stabilized supralinear network can give rise to bistable, oscillatory, and persistent activity

PNAS March 27, 2018 115 (13) 3464-3469; published ahead of print March 12, 2018 https://doi.org/10.1073/pnas.1700080115

Tim Herfurth, Tatjana Tchumatchenko

How linear response shaped models of neural circuits and the quest for alternatives

Current Opinion in Neurobiology, Volume 46, October 2017, Pages 234-240

Submitted:

Fonkeu, Y., Kraynyukova, N., Hafner. A-S., Sartori, F, Schuman, E.M., Tchumatchenko T. How mRNA localization and protein synthesis sites influence dendritic protein distribution and dynamics. Under review (2018)

C04 Laurent

Tosches MA, Yamawaki TM, Naumann RK, Jacobi AA, Tuschev G and Laurent G (2018). Evolution of pallium, hippocampus and cortical cell types revealed by single-cell transcriptomics in reptiles. Science 360 (6391): 881-888.

C05 Rumpel

Mongillo G, Rumpel S, Loewenstein Y (2018) Inhibitory connectivity defines the realm of excitatory plasticity. Nat. Neurosci. 21:1463–1470.

Other publications, also directly related to the CRC:

Chambers AR, Rumpel S (2017) A stable brain from unstable components: Emerging concepts and implications for neural computation. Neuroscience, 357:172-184

Mongillo G, Rumpel S, Loewenstein Y (2017) Intrinsic volatility of synaptic connections — a challenge to the synaptic trace theory of memory. Curr. Opin. Neurobiol. 46:7–13

Other publication, more loosely related to the CRC:

Aschauer D, Rumpel S (2018) The sensory neocortex and associative memory. Curr. Top. Behav. Neurosci. 37:177-211

C05 Loewenstein

Mongillo, G., Rumpel, S. and Loewenstein Y. (2017), Intrinsic volatility of synaptic connections – a challenge to the synaptic trace theory of memory, Current Opinion in Neurobiology, 46:7-13.

Elber-Dorozko, L. and Loewenstein, Y. (2018), Striatal action-value neurons reconsidered, eLife 7: e34248.


Mongillo, G., Rumpel, S. and Loewenstein, Y. (2018), Inhibitory connectivity defines the realm of excitatory plasticity, Nature Neuroscience, 21:1463–1470